Alles wat je moet weten over de huiduitslag veroorzaakt door het Epstein-Barr virus

Summary

The Epstein-Barr virus is a very common virus that will affect most people at some point during their lives. It doesn't always cause symptoms, but some people who are infected with it may develop mononucleosis.

The Epstein-Barr virus is associated with serious complications including certain kinds of cancer, autoimmune conditions, and chronic fatigue syndrome. Although it can be prevented with measures like hand washing and not sharing food, the fact that it is so prevalent and doesn't usually cause symptoms makes it difficult to avoid.

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1. Womack J, Jimenez M. Common questions about infectious mononucleosis. Am Fam Physician. 2015,91(6):372-376.
2. Stanfield BA, Luftig MA. Recent advances in understanding Epstein-Barr virus. F1000Res. 2017,6:386. doi:10.12688/f1000research.10591.1
3. Kang MS, Kieff E. Epstein-Barr virus latent genes. Exp Mol Med. 2015,47(1):e131. doi:10.1038/emm.2014.84
4. American Cancer Society. Viruses that can lead to cancer.
5. Nijland ML, Kersten MJ, Pals ST, Bemelman FJ, Ten Berge IJ. Epstein-Barr virus-positive posttransplant lymphoproliferative disease after solid organ transplantation: pathogenesis, clinical manifestations, diagnosis, and management. Transplant Direct. 2015,2(1):e48. doi:10.1097/TXD.0000000000000557
6. Dunmire SK, Grimm JM, Schmeling DO, Balfour HH Jr, Hogquist KA. The incubation period of primary Epstein-Barr virus infection: Viral dynamics and immunologic events. PLoS Pathog. 2015,11(12):e1005286. doi:10.1371/journal.ppat.1005286
7. Centers for Disease Control and Prevention. About infectious mononucleosis (mono).
8. Kimura H, Cohen JI. Chronic active Epstein-Barr virus disease. Front Immunol. 2017,8:1867. doi:10.3389/fimmu.2017.01867
9. Hutcheson RL, Chakravorty A, Sugden B. Burkitt lymphomas evolve to escape dependencies on Epstein-Barr virus. Front Cell Infect Microbiol. 2021,10:606412. doi:10.3389/fcimb.2020.606412
10. Velavan TP. Epstein-Barr virus, malaria and endemic Burkitt lymphoma. EBioMedicine. 2019,39:13-14. doi:10.1016/j.ebiom.2018.12.041
11. Gandhi MK, Hoang T, Law SC, et al. EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. Blood. 2021,137(11):1468-1477. doi:10.1182/blood.2020008520
12. Pedersen M, Asprusten TT, Godang K, et al. Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study. Brain Behav Immun. 2019,75:94-100. doi:10.1016/j.bbi.2018.09.023
13. Loebel M, Eckey M, Sotzny F, et al. Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray. PLoS One. 2017,12(6):e0179124. doi:10.1371/journal.pone.0179124
14. Houen G, Trier NH. Epstein-Barr virus and systemic autoimmune diseases. Front Immunol. 2020,11:587380. doi:10.3389/fimmu.2020.587380
15. Harley JB, Chen X, Pujato M, et al. Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. Nat Genet. 2018,50(5):699-707. doi:10.1038/s41588-018-0102-3
16. Centers for Disease Control and Prevention. Laboratory testing for Epstein-Barr virus (EBV).
17. Centers for Disease Control and Prevention. About Epstein-Barr virus.
18. Bu W, Joyce MG, Nguyen H, et al. Immunization with components of the viral fusion apparatus elicits antibodies that neutralize Epstein-Barr virus in B Cells and epithelial cells. Immunity. 2019,50(5):1305-1316.e6. doi:10.1016/j.immuni.2019.03.010

EBV Complications

There are many Epstein-Barr virus long-term effects. The virus can affect many parts of your body, including the nervous system, blood, and lungs. EBV may cause complications like:

EBV symptoms usually go away within 2 weeks to a month after you're infected. Then the virus goes dormant. But rarely, EBV symptoms don’t clear up. The virus stays active. A small number of people have symptoms like a fever, swollen glands, and an enlarged liver or spleen that come and go or get worse over time.

If you have symptoms and positive blood tests for at least 3 months, you may have a chronic active EBV infection. Your doctor will recommend treatments to manage your symptoms and help you feel better.

EBV reactivation symptoms

The virus can wake up after it has been dormant in your body and cause symptoms again. This is more likely to happen if you have a weak immune system.

Symptoms of EBV reactivation include:

• Fever
• Sore throat
• Swollen glands in the neck
• Swollen liver or spleen
• Tiredness

See your doctor if you or your child has any of these symptoms a few months after an EBV infection.

Bedeutung & Funktion

Grundsätzlich lässt sich die Erkrankung mit dem Epstein-Barr-Virus in einen akuten und einen chronischen Zustand unterscheiden. Gegenüber der akuten Erkrankung ist der serologische Antikörperbefund bei der chronischen Verlaufsform vielfach weniger eindeutig. Häufig sind bei der chronischen Form nur geringe Mengen einzelner Langzeitantikörper im Serum des Blutes vorhanden, die auch nach einer akuten Infektion dauerhaft im Blut enthalten sind. Sehr viel aussagekräftiger als der übliche Antikörpertest ist der Direktnachweis der Viren im Blut des Betroffenen. Hierdurch lässt sich eine chronische Infektion mit dem Epstein-Barr-Virus zuverlässig diagnostizieren.

Die aktuelle Immunlage des Körpers ist entscheidend dafür, ob und wie stark der Betroffene nach einer Infektion mit dem Epstein-Barr-Virus Krankheitssymptome zeigt. Somit muss eine Infektion bei einem intakten und starken Immunsystem keineswegs zwangsläufig zu einer Erkrankung führen. Sollte das Immunsystem des Betroffenen jedoch bereits geschwächt sein, können die Epstein-Barr-Viren ohne große Gegenwehr einzelne Körperregionen oder auch den gesamten Körper des Betroffenen befallen, wodurch sich verschiedene Symptome erklären lassen.