Graham Eczeem Review - Effectiviteit en Ervaringen

Pathophysiology

Research shows there is a genetic component to eczema. One common mutation has been observed in FLG, a vital gene for skin cell maturity. This gene is responsible for creating the tough, flat corneocytes that form the outermost protective layer of skin. In a patient with normal skin cells, the corneocytes are tightly packed in an organized manner. A patient with an FLG mutation will have a dysfunctional skin barrier due to the haphazard organization of the skin cells.[7] This dysfunction causes a "leaky" skin barrier, allowing water loss and decreased protection from harmful substances.

People with eczema also have reduced numbers of β-defensins in the skin. β-defensins are host defense peptides vital for fighting off certain bacteria, viruses, and fungi. A decrease in these peptides leads to increased colonization and infection, especially with Staphylococcus aureus (S. aureus).[8]

Introduction

Eczema, or atopic dermatitis, is the most common form of dermatitis.[1] Many factors, including genetic and environmental factors, are thought to play a part in the pathogenesis of eczema. It is most commonly seen in children but can be seen in adults as well. People with eczema tend to have dry, itchy skin prone to infection. The condition is commonly known as the "itch that rashes" because dry, itchy skin leads to a rash due to scratching or rubbing the skin.

The exact etiology of eczema is not entirely understood, but it is believed to be a combination of genetic and environmental factors.[2]

Genetic Factors

There is a strong genetic component to eczema, with a family history of eczema, asthma, or allergies commonly found in affected individuals. Several genes associated with eczema have been identified, including those involved in the skin barrier function and the immune system.

Filaggrin Gene

Other Skin Barrier Genes

In addition to the filaggrin gene, other genes involved in the skin barrier function have been implicated in the development of eczema. These include genes involved in lipid synthesis and transport, such as the ceramide synthase gene and the ABCA12 gene.[5]

Immune-related Genes

Several genes involved in the immune response have also been associated with eczema, including genes that regulate T-cells, cytokines, and immunoglobulins. These genes include interleukin (IL)-4, IL-13, IL-31, signal transducer and activator of transduction (STAT)3, and Fc fragment of immunoglobulin (Ig)E receptor Ig (FCER1G).

Overall, the genetic factors involved in eczema are complex and likely involve multiple genes and genetic pathways. Although genetic testing is not routinely used to diagnose eczema, understanding the disease's genetic basis can help identify individuals at increased risk and guide treatment approaches.

History and Physical

The distribution of the rash varies depending on patient age. Infants tend to have widely distributed, dry, scaly, and erythematous patches with small excoriations. They also tend to have lesions on their face, especially the cheeks. With age, the rash becomes more localized, areas affected include the extensor surfaces such as the wrists, elbows, ankles, and knees. School-aged children tend to follow the pattern seen in adults: the involvement of the flexural surfaces usually affects the anticubital and popliteal fosse.

The main management and treatment protocols for eczema include hydration and topical anti-inflammatory medications for flare-ups. The priority in treatment is focusing on a daily skin moisturizing regimen with a fragrance-free ointment with limited preservatives.[12] An ointment is preferred over a cream due to the high proportion of oil to water in lotions. Patients and caregivers should also identify and address any triggers. They should be instructed to avoid any environmental allergens, harsh soaps, detergents, fragrances as well as rough or nonbreathable fabrics.

Skin flare-ups can be treated with topical anti-inflammatory medications, such as topical steroids or steroid-free products like pimecrolimus, tacrolimus, or Eucirsa. In children, itching tends to be worse at nighttime. Oral antihistamines can be used intermittently at bedtime for disturbed sleep due to itch, however, antihistamines are no longer recommended for daytime use for itching in eczema. Patients with poorly controlled eczema have a higher risk of cutaneous infections. Patients and caregivers may be instructed to take diluted bleach baths or intranasal mupirocin to decrease the number of cutaneous infections.[13]

Beste eczeem crème

In deze blog geef ik antwoord op de vraag: wat is het beste middel tegen eczeem? Dit doe ik op basis wetenschappelijk bewijs, de ingrediëntenlijsten producten, ervaringen van anderen en mijn eigen ervaring.

Wel wil ik hierbij even zeggen dat eczeem klachten (zoals je waarschijnlijk als geen ander weet) lastig te behandelen zijn. Een product kan voor de ene persoon heel goed werken en voor de ander weinig doen. Ik kan daarom geen zekerheid geven dat onderstaande producten voor jou werken, maar ik heb wel hele goede hoop!

Het smeren van een goede eczeem crème is wat mij betreft de belangrijkste stap, maar ik geef in deze blog ook tips over de beste eczeem douche olie en beste eczeem zonnebrand- Hieronder vind je vier voorbeelden van producten die wat mij betreft door kunnen als beste eczeem crème!

1. Tiny Todd eczeem crème

Het beste middel tegen eczeem is voor mij op dit moment nog steeds de havercreme van Tiny Todd. Ik kwam dit product twee jaar geleden per toeval tegen op Instagram en sindsdien ben ik fan!

Sindsdien adviseer ik de crème aan allerlei eczeem gerelateerde klachten. Maar ook aan andere huidaandoeningen, zoals: jeuk, een allergische reactie, roodheid en ontstekingen. Het werkzame ingrediënt in de crème is namelijk haver, zowel haverolie als haverextract.

Haver wordt al eeuwen lang ingezet tegen allerlei huidproblemen vanwege de ontstekingsremmende en jeukstillende werking op de huid. Dit maakt het ook een heel geschikt extract voor de eczeem gevoelige huid.

2. Grahams eczeem crème

Een andere crème, die wat mij betreft ook door kan als beste eczeem crème, is deze Grahams eczeem crème. Net als de eczeem crème hierboven, bestaat ook deze crème voornamelijk uit haver. Alleen dan havermeel.